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Part numberHC22E1003 vs Totaline P110-1045
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HC22E1003
10 in W x 9.5 in H x 1.5 in D
Totaline P110-1045
10 in W x 9.5 in H x 1.5 in D
HC22E1003 fits
Honeywell HE100, HE150, HE220, HE225, HE240
Totaline P110-1045 fits
Carrier HUMCCSBP2212, HUMCCSBP2312, HUMCASBP2312, HUMCCSBP2412, HUMCASBP2412 small bypass humidifiers

Whether the HC22E1003 and Totaline P110-1045 humidifier pads interchange.

Interchangeable. The HC22E1003 and Totaline P110-1045 fit the same humidifiers.
Fitment notes

The HC22E1003 and the Totaline P110-1045 are in the same GA1 cross-reference group and share the same published size, 10 in W x 9.5 in H x 1.5 in D. A humidifier that takes one takes the other.

They are the same size, so the only real difference is brand and, on some pads, an antimicrobial coating. Buy whichever is cheaper for your unit and replace it once a season.

What to buy

Find your model

Read the number stamped on the humidifier cabinet or printed on the old pad, then match it below. Confirm the frame size before buying a generic.

Related

Sources: Honeywell Home HC22E1003 humidifier pad (Ferguson listing) · Carrier/Bryant/Payne/Totaline P110-1045 small bypass humidifier pad (Amazon) · Carrier/Bryant/Totaline small bypass pad P110-1045 model list (Walmart)