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Part numberHC22A1007 vs Totaline P110-1045
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HC22A1007
10 in W x 9.5 in H x 1.5 in D
Totaline P110-1045
10 in W x 9.5 in H x 1.5 in D
HC22A1007 fits
Honeywell HE100, HE150, HE220, HE225
Totaline P110-1045 fits
Carrier HUMCCSBP2212, HUMCCSBP2312, HUMCASBP2312, HUMCCSBP2412, HUMCASBP2412 small bypass humidifiers

Whether the HC22A1007 and Totaline P110-1045 humidifier pads interchange.

Interchangeable. The HC22A1007 and Totaline P110-1045 fit the same humidifiers.
Fitment notes

The HC22A1007 and the Totaline P110-1045 are in the same GA1 cross-reference group and share the same published size, 10 in W x 9.5 in H x 1.5 in D. A humidifier that takes one takes the other.

They are the same size, so the only real difference is brand and, on some pads, an antimicrobial coating. Buy whichever is cheaper for your unit and replace it once a season.

What to buy

Find your model

Read the number stamped on the humidifier cabinet or printed on the old pad, then match it below. Confirm the frame size before buying a generic.

Related

Sources: Honeywell Home HC22A1007 humidifier pad (Honeywell Home) · Honeywell Home standard replacement humidifier pad · Carrier/Bryant/Payne/Totaline P110-1045 small bypass humidifier pad (Amazon) · Carrier/Bryant/Totaline small bypass pad P110-1045 model list (Walmart)