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Part numberAprilAire 10 vs HC22A1007
adapter
AprilAire 10
9.75 in W x 10 in H x 1.75 in D
HC22A1007
10 in W x 9.5 in H x 1.5 in D
AprilAire 10 fits
AprilAire 110, 220, 500, 500A, 500M, 550, 550A, 558
HC22A1007 fits
Honeywell HE100, HE150, HE220, HE225

Whether the AprilAire 10 and HC22A1007 humidifier pads interchange.

Same fit group, different frame. The AprilAire 10 and HC22A1007 cover the same humidifiers but differ in size.
Fitment notes

The AprilAire 10 and the HC22A1007 sit in the same GA1 cross-reference group and cover the same humidifier slot, but the AprilAire 10 measures 9.75 in W x 10 in H x 1.75 in D while the HC22A1007 measures 10 in W x 9.5 in H x 1.5 in D.

Because the frame sizes differ slightly, seat the replacement fully against the water tray so water wicks through the pad rather than running down a gap at the edge. Either one fits the same humidifiers, but a pad that sits loose will drip past.

What to buy

Find your model

Read the number stamped on the humidifier cabinet or printed on the old pad, then match it below. Confirm the frame size before buying a generic.

Related

Sources: AprilAire Water Panel 10 product page · AprilAire Water Panel Guide · Honeywell Home HC22A1007 humidifier pad (Honeywell Home) · Honeywell Home standard replacement humidifier pad · Industry evaporator-pad cross-reference chart (2J Supply)